Helping pharma to develop safer drugs faster

Technology

ToxProfileTM

DCP ToxProfile evaluates a drug’s effect on a toxicity cell model by analyzing its quantitative proteome profile linked to interactions between drug and cellular proteins.

Process

  • Identify toxicity model (cell line or tissue)
  • Determine proteomic profile of drug in the system
  • Evaluate drug’s selectivity
  • Identify off-target interactions

Applications

  • Prediction of potential toxic liabilities
  • Selection of clinical candidate compounds
  • Analysis of drug mechanism in the system

Click here for more details on the ToxProfile

TargetIdTM

DCP TargetId technology uses quantitative proteomics to analyze the cellular proteome expression and localization profile following treatment with a drug.

Process

  • Identify cell line or tissue for analysis
  • Proteome-wide scanning for interacting partners to drugs
  • Identify new drug targets
  • Evaluate drug selectivity/specificity in cellular environment

Applications

  • Target identification and validation
  • Drug lead optimization
  • Clinical candidate selection
  • Drug mechanism and pathway discovery

Click here for more details on the TargetId

PhosProfileTM

DCP PhosProfile integrates phosphoproteomics and MS to analyze the effect of a drug on the phosphoproteome and signal transduction pathways.

Process

  • Analysis of phospho sites in cells, animal tissues and patient samples
  • Mapping of phospho sites in identified proteins
  • Identify new kinase targets
  • Cellular kinase profiling following drug treatment
  • Determine cellular mechanism of drug action

Applications

  • Target identification and validation
  • Drug lead optimization
  • Clinical candidate selection
  • Drug mechanism and pathway discovery

Click here for more details on the PhosProfile

BioMarkIdTM

DCP BioMarkId is a novel biomarker discovery platform designed to identify new biomarkers in complex biological systems including cells, patient tissues, animal models, etc.

Process

  • Identify sample or tissue of interest
  • Determine quantitative proteomics approach for biomarker identification
  • Biomarkers from infectious agents e.g. bacteria
  • Biomarker validation

Applications

  • Diagnostic biomarker discovery
  • Drug efficacy biomarkers identification
  • Prognostic biomarkers identification

Click here for more details on the BioMarkId