Helping pharma to develop safer drugs faster

Scientific publications

 

The scientific papers listed here are from the co-founders of the company, their collaborators as well as from scientists and institutions that have collaborated with the company in their R&D projects.

  • Novel blood collection method allows plasma proteome analysis from single zebrafish (2013) Babaei F, Ramalingam R, Tavendale A, Liang Y, Yan LS, Ajuh P, Cheng SH, Lam YW.  J. Proteome Res. Epub ahead of print
  • Characterization of carbon nanotube protein corona by using quantitative proteomics (2012) Cai X, Ramalingam R, Wong HS, Cheng J, Ajuh P, Cheng SH, Lam YW.  Nanomedicine. S1549-9634(12)00597-7.
  • A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture (2012) Dove BK, Surtees R, Bean TJ, Munday D, Wise HM, Digard P, Carroll MW, Ajuh P, Barr JN, Hiscox JA.  Proteomics. 12, 1431-1436
  • Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS (2010) C Munday D, Hiscox JA, Barr JN. Proteomics. 23, 4320-4334.
  • Quantitative phosphoproteomic analysis of prion-infected neuronal cells (2010) Wagner W, Ajuh P, Lower J and Wessler S. Cell Communication and Signaling 8:28
  • Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus (2010) Emmott E, Smith C, Emmett SR, Dove BK, Hiscox JA. Proteomics 19, 3558-62
  • Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus. (2010) Munday D, Emmott E, Surtees R, Lardeau CH, Wu W, Duprex WP, Dove BK, Barr JN, Hiscox JA. Mol. Cell. Proteomics. 9 (11), 2438-2459
  • Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus subgroup B using SILAC coupled to LC-MS/MS" (2010)  Munday DC, Hiscox JA, Barr JN. Proteomics. 23, 4320-4334.
  • Quantitative proteomics using stable isotope labeling with amino acids in cell culture (SILAC) reveals changes in the cytoplasmic, nuclear and nucleolar proteomes in Vero cells infected with the coronavirus infectious bronchitis virus. (2010) Emmott E, Rodgers M, Macdonald A, McCrory S, Ajuh P, Hiscox JA. Mol Cell Proteomics. 9, 1920-1936
  • Quantitative Proteomics Using SILAC Coupled to LC-MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells (2010) Emmott E, Wise H, Loucaides EM, Matthews DA, Digard P, Hiscox JA. J. Proteome Res. 9 (10), 5335-5345
  • A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58. (2010) Westman BJ, Verheggen C, Hutten S, Lam YW, Bertrand E, Lamond AI. Mol Cell. 39, 618-631
  • Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. (2010) Llères D, Denegri M, Biggiogera M, Ajuh P, Lamond AI. EMBO Rep. 6, 445-451
  • A quantitative proteomics analysis of subcellular proteome localization and changes induced by DNA damage. (2010) Boisvert FM, Lam YW, Lamont D, Lamond AI. Mol Cell Proteomics 9, 457-470.
  • Establishment of a protein frequency library and its application in the reliable identification of specific protein interaction partners. (2010) Boulon S, Ahmad Y, Trinkle-Mulcahy L, Verheggen C, Cobley A, Gregor P, Bertrand E, Whitehorn M, Lamond AI. Mol Cell Proteomics 9, 861-879.
  • Quantitative proteomics using stable isotope labeling with amino acids in cell culture (SILAC) reveals changes in the cytoplasmic, nuclear and nucleolar proteomes in Vero cells infected with the coronavirus infectious bronchitis virus. (2010) Emmott E, Rodgers M, Macdonald A, McCrory S, Ajuh P, Hiscox JA. Mol. Cell. Proteomics 9, 1920-1936
  • Repo-Man recruits PP1γ to chromatin and is essential for cell viability (2006) Trinkle-Mulcahy, L., Andersen, J., Lam, Y.W., Moorhead, G., Mann, M. and Lamond, A.I. J. Cell Biol. 172:679-92.
  • Nucleolar proteome dynamics" (2005) Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M. Nature, 433:77-83.
  • Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions (2005) Pendle, A.F., Clark, G.P., Boon, R., Lewandowska, D., Lam, Y.W., Andersen, J., Mann, M., Lamond, A.I., Brown, J.W. and P.J. Shaw. Mol. Biol. Cell 16:260-9.
  • A Proteomic Study of SUMO-2 Target Proteins (2004) Vertegaal, A.C.O., Ogg, S.C., Jaffray, E., Rodriguez, M.S., Hay, R.T., Andersen, J.S., Mann, M. and Lamond, A.I. J.Biol. Chem., 279:33791-33798.
  • Proteomics of the nucleolus; Lam, Y.W., Fox, A.H., Leung, A.K., Andersen, J., Mann, M. and Lamond, A.I. (2004) in “The Nucleolus” Olsen, Mark O.J. (Ed) Kluwer Academic/Plenum 16 pp. 302-314.
  • Large-scale proteomic analysis of the human spliceosome. Rappsilber, J., Ryder, U., Lamond A.I. and Mann, M. (2002) Genome Research, 8:1231-1245.
  • Directed Proteomic Analysis of the Human Nucleolus; Andersen, J.S., Lyon, C.E., Fox, A., Leung, A., Lam, Y.W., Steen, H., Mann, M. and Lamond, A.I. (2002) Current Biology, 12:1-11.
  • SPF30, an essential human splice factor required for assembly of U4/U5/U6 tri-snRNP into the spliceosome. Rappsilber, J., Ajuh, P.M., Lamond, A.I. and Mann, M. (2001) J. Biol. Chem. 276:31142-31150.
  • Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. Ajuh, P.M., Kuster, B., Panov, K., Zomerdijk, J.C.B.M., Mann, M. and Lamond, A.I. (2000) EMBO J. 19:6569-81.
  • Mass Spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex; Neubauer, G., King, A., Rappsilber, J., Calvio, C., Watson, M., Ajuh, P., Sleeman, J., Lamond, A. and Mann, M. (1998) Nature Genetics 20, pp 46-50.